The Intricate Link: Brain Dominance and Mental Health

Brain dominance may relate to mental health issues like schizophrenia, bipolar disorder, and depression. Research suggests the left hippocampus is vulnerable in first-episode psychosis, while bipolar disorder may involve the right hemisphere. Major depression is linked to the left hippocampus. In epilepsy, left-brain lesions lean toward psychotic conditions, and right-brain lesions toward mood disorders. The cause-effect relationship remains unclear.


The intricacies of the human brain continue to baffle even the most learned of neuroscientists. As our understanding of the brain’s two hemispheres (leftbrained and rightbrained) has deepened, curious questions about their association with specific mental health issues arise. How does one’s predisposition towards being left or rightbrained affect their susceptibility to certain mental health conditions? The answer, as we will uncover, is complex and multifaceted.

1. Creativity and Mental Health:  

Historically, many of the world’s most renowned creators, from artists to poets, have battled mental health conditions. Professor Michael Trimble, in his book “Soul in the Brain,” illustrates the compelling nexus between creativity (often associated with rightbrained dominance) and the prevalence of mental disorders. Celebrated figures like Subramanian Bharati underscore this connection, marrying profound creativity with personal emotional struggles. This serves to emphasize the curious intersection of rightbrained dominance, creativity, and mental health.

2. The Enigma of the Hippocampus:  

Central to this conversation is the hippocampus, a small, pivotal structure in the brain responsible for memory storage. Research, especially in the realm of schizophrenia, consistently points towards an intriguing pattern: the left hippocampus seems to deteriorate first during the initial stages of psychosis and with subsequent episodes. Such findings weave a tentative tapestry of connections between the left hemisphere and schizophrenia.

3. Other Mental Health Conditions and Brain Dominance:  

Delving further, studies indicate potential associations between the right hemisphere and bipolar disorder, particularly mania. Contrastingly, major depressive disorder shows links with the left hippocampus. It’s crucial to note that these correlations, while fascinating, stem from MRI studies conducted on patients who’ve already presented symptoms. As a result, it remains unclear if these findings are the causes or consequences of the respective mental health conditions.

4. Personal Experiences in Epilepsy Research:  

Epilepsy, a neurological disorder characterized by recurrent seizures, offers further insights into the hemi spheremental health conundrum. Observational studies involving individuals with epilepsy have unveiled patterns: those with left brained lesions tend to experience psychotic conditions, while rightbrained lesions appear to correlate with mood disorders.

5. The Verdict:  

The realm of neuropsychiatry remains vast and relatively uncharted. While recent findings shine a light on potential hemisphere based predispositions to certain mental disorders, they also spotlight our collective knowledge gaps. The cause effect relationship is yet to be definitively discerned, leaving scientists and clinicians with more questions than answers.


The labyrinth of the human brain holds secrets and stories still waiting to be uncovered. While we’ve made significant strides in understanding potential hemisphere based predispositions to mental health issues, much remains to be explored, understood, and deciphered. The dance between our brain’s hemispheres and our mental wellbeing is intricate, delicate, and infinitely captivating.

The brain’s melodies, harmonized by its two hemispheres, sing songs of both creativity and chaos, revealing the symphony of our mental wellbeing.

Explanation of the Quote:  

The quote encapsulates the profound and intricate relationship between the brain’s two hemispheres and our mental health. Just as melodies and harmonies come together to create music, the combined influences of both hemispheres, with their distinct predispositions, converge to shape our mental state sometimes leading to creativity, at other times to tumult.

Oliver The Brainy Owl

Oliver The Brainy Owl

Oliver, whose musings speak for & to us is our Mascot. Inspired by his namesake the erudite neurologist & writer Late Professor Oliver Sacks, he shares periodically, pearls of wisdom about the brain and mind. Hailing from a long lineage that has been associated with health over millennia, Oliver traces his ancestry to Athena & Minerva the Greek & Roman goddesses of health, philosophy & magic. Not to be mistaken for his comic counterpart...

Leave a Reply

Your email address will not be published. Required fields are marked *

at Neurokrish

We'll ask for some basic information to assess your requirements.