In this episode of Neurokrish Immersion, Dr. Ennapadam S Krishnamoorthy speaks with Dr. Jesus Ramirez-Bermudez, renowned neuropsychiatrist and author, about his essay Finitude and Melancholy. Together, they journey through history, literature, and philosophy to unpack the relationship between melancholy and creativity, and how the awareness of mortality, our finitude, can lead to deeper meaning and purpose. Drawing on the lives of poets, patients, and thinkers, the conversation moves beyond diagnosis to reflection, introspection, and the power of metacognition.